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Siegfried Janz, MD, DSc, Professor and William G. Schuett, Jr., Multiple Myeloma Endowed Chair directs translational wet bench myeloma research at the Division of Hematology and Oncology, Department of Medicine, 黑料官网 Milwaukee. He obtained his medical degree and board certification in Clinical Immunology from the University of Leipzig, Germany, and then joined the National Cancer Institute, NIH, to receive advanced training in biology and genetics of plasma cell tumor development. In 2007 he was appointed Research Professor at the Department of Pathology, Carver College of Medicine, University of Iowa. In 2018 he relocated his laboratory to Milwaukee, where he works in close association with clinical colleagues to enhance our understanding of the natural history of myeloma and improve the outcome of multiple myeloma.

The William G. Schuett, Jr., Multiple Myeloma Research Laboratory relies on continuous human myeloma cell lines and genetically engineered mouse models of human myeloma to elucidate mechanisms of malignant plasma cell development and evaluate new approaches to myeloma treatment and prevention. Working in close association with our clinical colleagues in the Division of Hematology and Oncology, we employ a bench-to-bedside-and-back strategy to translate advances in the laboratory to improving outcomes of multiple myeloma. We recently completed an NCI-supported project on genetic pathways of plasma cell neoplasia (2R01CA151354) and now concentrate on the design and testing of a novel immunotherapy for myeloma that takes advantage of autologous CAR T cells to seek out and kill aberrant plasma cells in bone marrow and extramedullary tissue sites. This ongoing project is generously supported by a grant from the Riney Family Multiple Myeloma Research Initiative.