黑料官网

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Research Group Lab Hall
Pharmacology and Toxicology
Wei Liu, PhD

Wei Liu, PhD

Joseph F. Heil, Jr. Endowed Chair of Molecular Oncogenesis; Co-Leader, Cancer Biology Program, Cancer Center; Director, Structural Biology Shared Resource (SBSR), Cancer Center; Professor, Pharmacology and Toxicology

Locations

  • Pharmacology and Toxicology
    TBRC 3910

Contact Information

Education

PhD, The Ohio State University, Columbus, OH

Biography

Dr. Wei Liu joined the 黑料官网 in 2022. Prior to his appointment at 黑料官网, he was a tenured associate professor at the School of Molecular Sciences and the Biodesign Institute at Arizona State University. Before joining ASU, he conducted research at The Scripps Research Institute. Over more than a decade, Dr. Liu developed innovative tools and approaches to study the structure and function of membrane proteins, with a particular emphasis on G protein–coupled receptors (GPCRs) implicated in cancer.

Honors and Awards

2017-2021 Thomson Reuters Highly Cited Researchers

Research Interests

Structural biology has a profound impact on biomedical research by revealing the architecture of nature’s fundamental building blocks and providing a foundation for the rational design of interventions that enhance human health. Our laboratory integrates a broad spectrum of tools, expertise, and methodologies to accelerate the structure-to-function pipeline for G protein–coupled receptors (GPCRs). We employ high-throughput (HT) screening to optimize construct design, followed by Cryo-EM and X-ray diffraction–based structure determination. The resulting high-resolution structural data inform computational drug screening and iterative structure-based drug design (SBDD), enabling precise optimization of ligand binding to GPCRs and other drug targets. These efforts are further strengthened through collaborations with industry partners including Pfizer, Eli Lilly, Allergan, and Abilita Therapeutics, focusing on the development of next-generation therapeutics guided by SBDD.

Publications

  • (Zhang B, Huang H, Zou X, Li X, He J, Xu N, Liu B, Shen X, Liu W.) Biochim Biophys Acta Mol Basis Dis. 2025 Oct;1871(7):167967 PMID: 40614386 SCOPUS ID: 2-s2.0-105009498782 07/05/2025

  • (He J, Guo J, Liu S, Li H, Ma Y, Ma S, Hu Z, Zhao W, Tan M, Liu W, Liu B.) Cell Signal. 2025 Jun;130:111665 PMID: 39986359 SCOPUS ID: 2-s2.0-85218907304 02/23/2025

  • (He J, Liu S, Zhang S, Gao Q, Zhu L, Xu N, Hu Z, Zhang X, Ma S, Wang X, Liu B, Liu W.) Sci Rep. 2025 Mar 04;15(1):7605 PMID: 40038413 PMCID: PMC11880390 SCOPUS ID: 2-s2.0-86000087831 03/05/2025

  • (Liu S, Payne AM, Wang J, Zhu L, Paknejad N, Eng ET, Liu W, Miao Y, Hite RK, Huang XY.) Nat Struct Mol Biol. 2025 Mar;32(3):469-478 PMID: 39543315 SCOPUS ID: 2-s2.0-85208990896 11/15/2024

  • (Cheng W, Liu S, He J, Li H, Liu X, Hu Z, Wang X, Wu Z, Xu G, Liu W, Liu B.) Biochem Biophys Res Commun. 2025 Feb 16;749:151323 PMID: 39842333 SCOPUS ID: 2-s2.0-85215431954 01/23/2025

  • (Zhang L, Liu S, He J, Hu Z, Zhu L, Huang H, Gao Q, Wang D, Chen L, Zhang X, Liu R, Wang J, Song Y, Zeng K, Li X, Chen Y, Zou X, Ma S, Wang X, Xu G, Liu W, Liu B.) Sci Rep. 2025 Jan 18;15(1):2384 PMID: 39827217 PMCID: PMC11742918 SCOPUS ID: 2-s2.0-85216439171 01/20/2025

  • (Barbosa ED, Ma Y, Clift HE, Olson LJ, Zhu L, Liu W.) ACS Chem Neurosci. 2024 Nov 20;15(22):4123-4131 PMID: 39485723 SCOPUS ID: 2-s2.0-85208389275 11/01/2024

  • (Du B, Chen T, Huang A, Chen H, Liu W.) Sensors (Basel). 2024 Oct 31;24(21) PMID: 39517898 PMCID: PMC11548145 SCOPUS ID: 2-s2.0-85208578596 11/13/2024

  • (Geng T, Sun Q, He J, Chen Y, Cheng W, Shen J, Liu B, Zhang M, Wang S, Asan K, Song M, Gao Q, Song Y, Liu R, Liu X, Ding Y, Jing A, Ye X, Ren H, Zeng K, Zhou Y, Zhang B, Ma S, Liu W, Liu S, Ji J.) Cell Signal. 2024 Jul;119:111180 PMID: 38642782 SCOPUS ID: 2-s2.0-85190884720 04/21/2024

  • (Ji J, Qian Q, Cheng W, Ye X, Jing A, Ma S, Ding Y, Ma X, Wang Y, Sun Q, Wang X, Chen Y, Zhu L, Yuan Q, Xu M, Qin J, Ma L, Yang J, Zhang M, Geng T, Wang S, Wang D, Song Y, Zhang B, Xu Y, Xu L, Liu S, Liu W, Liu B.) Cell Death Dis. 2024 May 13;15(5):332 PMID: 38740744 PMCID: PMC11091054 SCOPUS ID: 2-s2.0-85192951272 05/14/2024

  • (Ji J, Jing A, Ding Y, Ma X, Qian Q, Geng T, Cheng W, Zhang M, Sun Q, Ma S, Wang X, Yuan Q, Xu M, Qin J, Ma L, Yang J, He J, Du Q, Xia M, Xu Y, Chen Z, Zhu L, Liu W, Liu S, Liu B.) Cell Death Dis. 2024 Jan 11;15(1):33 PMID: 38212299 PMCID: PMC10784456 SCOPUS ID: 2-s2.0-85182091692 01/12/2024

  • (Tan B, Liu C, Li K, Jadhav P, Lambrinidis G, Zhu L, Olson L, Tan H, Wen Y, Kolocouris A, Liu W, Wang J.) J Med Chem. 2023 Nov 09;66(21):14544-14563 PMID: 37857371 PMCID: PMC11457037 SCOPUS ID: 2-s2.0-85176509223 10/20/2023

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