黑料官网

header-logo
Research Lab Bench
Physiology
Curt Sigmund

Curt D. Sigmund, PhD

James J. Smith & Catherine Welsch Smith Professor of Physiology; Chair of Physiology; Associate Director, Cardiovascular Research Center

Locations

  • Basic Science Building
    573A

Contact Information

Learn more about the Curt Sigmund Laboratory

Biography

Dr. Sigmund is the James J. Smith & Catherine Welsch Smith Chair of Physiology at the 黑料官网. Dr. Sigmund previously served as Professor and Roy J. Carver Chair in Hypertension Research; Director, Chair and Department Executive Officer, Department of Pharmacology; UIHC Center for Hypertension Research at the Roy J. and Lucille A. Carver College of Medicine at the University of Iowa. He has published over 250 papers, chapters, and reviews and has trained over 50 PhD students and postdoctoral fellows many of whom hold research and faculty positions nationally and internationally. He has held numerous leadership roles in prominent societies. He recently was elected to serve a two-year term as the new Chair-Elect of the American Heart Association Council on Hypertension and is currently the Chair of the Publications Committee of the American Physiological Society (APS). He was previously Associate Editor and Editor-in-Chief for several APS journals. He served on the External Scientific Review Board of the 黑料官网 Cardiovascular Center (now the Cardiovascular Research Center) from 2016-2017 and serves as its Associate Director.

Research Interests

Dr. Sigmund’s major areas of research focus on central nervous system and vascular mechanisms of blood pressure regulation by the renin-angiotensin system, the transcription factor PPAR-gamma, and its downstream effectors Cullin-3/RhoBTB1, investigating these using a combination of molecular biological, genetic and physiological approaches including the generation of unique transgenic and knockout models. Dr. Sigmund’s laboratory is located within the Cardiovascular Research Center in the Health Research Center and Medical Education buildings.

Publications

  • (Golosova D, Kumar G, Lu KT, Muskus Veitia PC, Hantke Guixa A, Wackman KK, Fekete EM, Brozoski DT, Grobe JL, Sequeira-Lopez MLS, Gomez RA, Nakagawa P, Sigmund CD.) JCI Insight. 2025 Aug 08;10(15) PMID: 40627460 PMCID: PMC12333948 SCOPUS ID: 2-s2.0-105013217775 07/08/2025

  • (Pasos J, Wagner VA, Lawton SBR, Madison AM, Nandani K, Mathieu NM, Grobe CC, Reho JJ, Freudinger BP, Sherman AJ, Brozoski DT, Morselli LL, Burnett CML, Segar JL, Nakagawa P, Sigmund CD, Grobe JL.) iScience. 2025 Jul 18;28(7):112797 PMID: 40585361 PMCID: PMC12205624 07/01/2025

  • (Golosova D, Kumar G, Chaihongsa N, Reho JJ, Lu KT, Brozoski DT, Wackman KK, Lawton SBR, Muskus PC, Lin BL, Grobe JL, Nakagawa P, Sigmund CD.) Hypertension. 2025 Jul;82(7):1208-1220 PMID: 40440505 PMCID: PMC12176512 SCOPUS ID: 2-s2.0-105005164668 05/29/2025

  • (Fekete ÉM, Gomez J, Ghobrial M, Kaminski K, Muskus PC, Boychuk CR, Hantke Guixa A, Vazirabad I, Xie M, Ganiyu A, Golosova D, Mathieu NM, Wang YB, Lu KT, Wackman KK, Brozoski DT, Mouradian GC, Hodges MR, Segar JL, Grobe JL, Sigmund CD, Nakagawa P.) Hypertension. 2025 Feb;82(2):282-292 PMID: 39618396 PMCID: PMC11735315 SCOPUS ID: 2-s2.0-85210962734 12/02/2024

  • (Pasos J, Wagner VA, Lawton SBR, Madison AM, Nandani K, Mathieu NM, Grobe CC, Reho JJ, Freudinger BP, Sherman AJ, Brozoski DT, Morselli LL, Burnett CML, Segar JL, Nakagawa P, Sigmund CD, Grobe JL.) Iscience. 18 July 2025;28(7) SCOPUS ID: 2-s2.0-105007661529 07/18/2025

  • (Golosova D, Kumar G, Chaihongsa N, Reho JJ, Lu KT, Brozoski DT, Wackman KK, Lawton SBR, Muskus PC, Lin BL, Grobe JL, Nakagawa P, Sigmund CD.) Hypertension. 1 July 2025;82(7):1208-1220 SCOPUS ID: 2-s2.0-105005164668 07/01/2025

  • (Ziegler AA, Lawton SBR, Fekete EM, Brozoski DT, Wagner VA, Grobe CC, Sigmund CD, Nakagawa P, Grobe JL, Segar JL.) Am J Physiol Regul Integr Comp Physiol. 2025 Jan 01;328(1):R109-R120 PMID: 39548798 PMCID: PMC11905802 SCOPUS ID: 2-s2.0-85213215949 11/16/2024

  • (Lawton SBR, Wagner VA, Nakagawa P, Segar JL, Sigmund CD, Morselli LL, Grobe JL.) Hypertension. 2024 Nov;81(11):2209-2217 PMID: 39315447 PMCID: PMC11483214 SCOPUS ID: 2-s2.0-85205521844 09/24/2024

  • (Medrano S, Yamaguchi M, Almeida LF, Smith JP, Yamaguchi H, Sigmund CD, Sequeira-Lopez MLS, Gomez RA.) Am J Physiol Renal Physiol. 2024 Sep 01;327(3):F489-F503 PMID: 38991008 PMCID: PMC11460331 SCOPUS ID: 2-s2.0-85201991983 07/11/2024

  • (Mathieu NM, Tan EE, Reho JJ, Brozoski DT, Muskus PC, Lu KT, Wackman KK, Grobe JL, Nakagawa P, Sigmund CD.) Hypertension. 2024 Jun;81(6):1332-1344 PMID: 38629290 PMCID: PMC11096025 SCOPUS ID: 2-s2.0-85193429264 04/17/2024

  • (Reho JJ, Muskus PC, Bennett DM, Grobe CC, Burnett CML, Nakagawa P, Segar JL, Sigmund CD, Grobe JL.) Am J Physiol Regul Integr Comp Physiol. 2024 Mar 01;326(3):R242-R253 PMID: 38284128 PMCID: PMC11213288 SCOPUS ID: 2-s2.0-85186271298 01/29/2024

  • (Cavallero S, Roustaei M, Satta S, Cho JM, Phan H, Baek KI, Blázquez-Medela AM, Gonzalez-Ramos S, Vu K, Park SK, Yokota T, Sumner J, Mack JJ, Sigmund CD, Reddy ST, Li R, Hsiai TK.) Sci Adv. 2024 Feb 16;10(7):eadj7481 PMID: 38354249 PMCID: PMC10866565 SCOPUS ID: 2-s2.0-85185344629 02/14/2024

Publications of from the

© 2025 黑料官网.  All rights reserved.  | Terms and Privacy | Web Accessibility Statement

Non-Discrimination, Anti-Harassment, and Legal Compliance Statement
The 黑料官网 (黑料官网) is committed to fostering a diverse community of outstanding faculty, staff, and students, as well as ensuring equal educational opportunity, employment, and access to services, programs, and activities, without regard to an individual's race, color, national origin, religion, age, disability, sex, gender identity/expression, sexual orientation, marital status, pregnancy, predisposing genetic characteristic, military status, or other legally protected classification. 黑料官网 maintains full compliance with all applicable federal, state, and local laws and regulations in pursuit of our missions. Consistent with federal guidance, we affirm our commitment to individual merit, fairness, and equal treatment in all aspects of academic and institutional decision-making.

黑料官网's policies, federal and state laws, and regulations prohibit unlawful discrimination and harassment. Employees, learners, students, applicants, or other members of the 黑料官网 community (including but not limited to vendors, visitors, and guests) may not be subjected to harassment that is prohibited by law or treated adversely or retaliated against based upon a protected characteristic.