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Zachary Smith, DO, MSc

Associate Professor

Location

  • Gastroenterology and Hepatology - Froedtert Hospital
  • 8850 William Coffey Dr.
  • Milwaukee, WI 53226

Specialties

  • Gastroenterology

New & Established Patients Call

I pride myself on establishing a meaningful relationship with all patients I care for. As an interventional endoscopist, I often see patients that are referred from other gastroenterologists and physicians for complex endoscopic problems. This occasionally results in meeting the patient for the first time right before his/her procedure. I make every effort to explain the problem, and the treatment plan to the patient and his/her loved one(s) so that they understand what we propose to do and what the next steps will be. Additionally, I place a high value on multidisciplinary care and collaboration. Many patients I treat are also cared for by other specialists and in these circumstances, input from the entire treatment team is imperative to optimize patient outcomes. Further, some conditions such as pancreatic fluid collections have various treatment options that span disciplines such as hepato-pancreaticobiliary surgery and interventional radiology. Only when we discuss and plan treatment strategies in a collaborative manner, are we able to achieve the best outcomes for our patients.

Overview

Diseases and Conditions

  • Barrett's Esophagus
  • Bile Duct Cancer
  • Esophageal Cancer
  • Gastric Cancer
  • Pancreatic Cancer
  • Pancreatitis
  • Pancreatobiliary Disease
  • Polyps
  • Bile Duct Disorders
  • Pancreatic Fluid Collections

Treatments and Services

  • Stenting of the GI Tract
  • ERCP
  • Endoscopic Ultrasound (EUS)
  • Endoscopic Mucosal Resection (EMR)
  • Interventional Endoscopy
  • Endoscopic Suturing
  • Endotherapy for Barrett's Esophagus
  • Endoscopic Management of Perforations, Leaks and Fistulas

Patients Ages Seen

  • Adult
  • Senior

Languages

  • English

Hospital Affiliations

  • Froedtert Hospital – Milwaukee
  • Zablocki VA Medical Center – Milwaukee

Board Certifications

  • Gastroenterology
  • Internal Medicine

Clinic Locations

map of clinics' locations

Biography

Dr. Smith did his Gastroenterology and Hepatology training at the 黑料官网. After pursuing subspecialty training in interventional endoscopy at Washington University School of Medicine in St. Louis, and spending three years on faculty at Case Western Reserve University School of Medicine in Cleveland, he returned to 黑料官网 in 2020 to join the faculty in the Division of Gastroenterology and Hepatology. His clinical expertise is interventional endoscopy and pancreaticobiliary disorders. Dr. Smith has extensive research interests in many fields of gastrointestinal endoscopy and his primary research focus at 黑料官网 is to design and conduct clinical trials and other high-impact studies that will help shape best practices of gastrointestinal endoscopy in the future.

Education and Training

Doctor of Osteopathic Medicine - Michigan State University College of Osteopathic Medicine - East Lansing, MI (2009)
Residency in Internal Medicine - University of Chicago Pritzker School of Medicine - Evanston, IL (2009-2012)
Chief Resident - Internal Medicine - University of Chicago Pritzker School of Medicine - Evanston, IL (2012-2013)
Fellowship in Gastroenterology and Hepatology - 黑料官网 Affiliated Hospitals - Milwaukee, WI (2013-2016)
Fellowship in Interventional Endoscopy - Washington University School of Medicine - St. Louis, MO (2016-2017)
Master of Science (MSc) in Clinical Trials - University of Oxford - Oxford (2022-2024)

Publications

  • (Gupta M, Fazal MA, Hammal J, Khan R, Forbes N, CReATE Working Group.) Clin Gastroenterol Hepatol. 2026 Mar;24(3):851-853 PMID: 40716626 SCOPUS ID: 2-s2.0-105014598584 07/29/2025

  • (Smith ZL, Amjad T, Hoard M, Thorgerson A, Chisholm PR, Dua KS, Elmunzer BJ, Forbes N, Madhavan S, Keswani RN, Peller MT, Wani S, Zia H, Dawson AZ, Yu D.) Clin Gastroenterol Hepatol. 2026 Feb 17 PMID: 41713828 02/20/2026

  • (Smith ZL.) Lancet Gastroenterol Hepatol. 2026 Feb;11(2):95-96 PMID: 41512885 SCOPUS ID: 2-s2.0-105026725535 01/10/2026

  • (Medawar E, Pohl H, Rex DK, Levenick JM, Pleskow DK, Khashab MA, Moyer M, Yang D, Melson J, Wallace MB, Mosko JD, Shahidi NC, Singh A, Gavric A, Djinbachian R, Gordon SR, Ngamruengphong S, Taunk P, Barber J, Piraka C, Elmunzer BJ, Aslanian HR, Elatrache M, Zolotarevsky E, Rastogi A, von Renteln D, Additional members of the Large Polyp Study Consortium.) Endoscopy. 2026 Feb;58(2):163-173 PMID: 40719106 07/28/2025

  • (Pohl H, Rex DK, Barber J, Moyer MT, Elmunzer BJ, Rastogi A, Gordon SR, Zolotarevsky E, Levenick JM, Aslanian HR, Elatrache M, von Renteln D, Wallace MB, Brahmbhatt B, Keswani RN, Kumta NA, Pleskow DK, Smith ZL, Abu Ghanimeh MK, Simmer S, Sanaei O, Mackenzie TA, Piraka C.) Gut. 2025 Oct 08;74(11):1804-1813 PMID: 40393701 PMCID: PMC12925415 SCOPUS ID: 2-s2.0-105005628880 05/21/2025

  • (Smith ZL, Forbes N, Madhavan S, Pohl H, Schauer JM, Steinbrück I, von Renteln D.) Curr Gastroenterol Rep. 2025 Sep 18;27(1):62 PMID: 40965773 SCOPUS ID: 2-s2.0-105016592118 09/18/2025

  • (Yachimski P, Zhang J, Coté GA, Edmundowicz SA, Wani S, Shah R, Bang JY, Varadarajulu S, Singh VK, Khashab M, Kwon RS, Scheiman JM, Willingham FF, Keilin SA, Papachristou GI, Chak A, Slivka A, Mullady D, Kushnir V, Buxbaum J, Keswani R, Gardner TB, Forbes N, Rastogi A, Ross A, Law J, Chen YI, Barkun A, Smith ZL, Serrano J, Petersen B, Wang AY, Saltzman JR, Spitzer RL, Ordiah C, Spino C, Foster LD, Durkalski-Mauldin V, Elmunzer BJ, SVI Study Group.) Gastrointest Endosc. 2025 Sep;102(3):375-381.e1 PMID: 39914634 SCOPUS ID: 2-s2.0-86000360999 02/07/2025

  • (Smith ZL, Kayal A, Ruan Y, Lethebe BC, Siersema PD, Padrón AT, Alshammari Y, Samnani S, Koury HF, Chau M, Howarth M, Cartwright S, Brenner DR, Tavakkoli A, Keswani RN, Elmunzer BJ, Wani S, Forbes N, CReATE Working Group.) J Can Assoc Gastroenterol. 2025 Apr;8(2):63-70 PMID: 40224576 PMCID: PMC11991873 04/14/2025

  • (Smith ZL.) Am J Gastroenterol. 2025 Mar 04;120(9):2204-2205 PMID: 40029061 SCOPUS ID: 2-s2.0-105000890965 03/03/2025

  • (Bishay K, Meng ZW, Khan R, Gupta M, Ruan Y, Vaska M, Iannuzzi J, O'Sullivan DE, Mah B, Partridge ACR, Henderson AM, Guo H, Samnani S, DeMarco M, Yuan Y, Elmunzer BJ, Keswani RN, Wani S, Smith ZL, Bridges RJ, Heitman SJ, Hilsden RJ, Brenner DR, Leontiadis GI, Forbes N.) Gastroenterology. 2025 Mar;168(3):568-586 PMID: 39515394 SCOPUS ID: 2-s2.0-85211230172 11/13/2024

  • (Smith ZL, Kayal A, Ruan Y, Lethebe BC, Siersema PD, Padrón AT, Alshammari Y, Samnani S, Koury HF, Chau M, Howarth M, Cartwright S, Brenner DR, Tavakkoli A, Keswani RN, Elmunzer BJ, Wani S, Forbes N, Chen YI, Barkun AN, Singh A, Hookey L, Arya N, Calo NC, Grover SC, Lei Y, Li S, Mohamed R, Turbide C, Bishay K, Gonzalez-Moreno E, Meng ZW, Heitman SJ.) Journal of the Canadian Association of Gastroenterology. 1 April 2025;8(2):63-70 SCOPUS ID: 2-s2.0-105002687672 04/01/2025

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