黑料官网

Dr. Abedin's clinical and research interests are in the treatment of patients with myeloid malignancies including acute myeloid leukemia (AML), and complications after allogeneic HCT, including Graft-versus-host disease.

Dr. Atallah's primary interest is in the treatment of patients with leukemia, myelodysplastic syndromes (MDS) and myeloproliferative disorders with special emphases on the treatment of patients with chronic myelogenous leukemia (CML). He is co-Principal Investigator (PI) with Dr. Kathryn Flynn, MD on an R01 from the National Cancer Institute (NCI) to evaluate stopping tyrosine kinase inhibitors in patients with CML who are in complete molecular remission. He is currently the administrative director of the Jean Khoury Cure CML consortium (HJKC3) which is housed at 黑料官网. In addition, he is the Clinical basket chair for patients < 60 with AML in the NCI myelomatch precision medicine initiative.

Dr. Carlson's research focus is on hematopoiesis. Using a novel mouse model system, she has identified a requisite component of the early lymphopoietic niche. She is now working to elucidate the biochemical regulation of this niche and its spatial localization within the bone marrow. Her research activities provide information about the basic biology of the hematopoietic stem cell and early lymphocyte developmental environment and characterize new targets for niche-directed therapy. Her long-term goal is to identify novel targets for the treatment of bone marrow failure syndromes and hematopoietic malignancies. Dr. Carlson is the recipient of a K08 mentored career development award from the National Heart Lung and Blood Institute.

Dr. Chen's research focuses on the role of micronutrients in regulating graft-versus-host disease (GVHD). His lab is investigating how vitamin A and vitamin D affect GVHD risk after allogeneic stem cell transplantation using animal models. He is also investigating how to target nuclear receptors to mitigate GVHD. Ongoing research uses genetic, nutritional, and pharmacological approaches to examine the complex interactions among the intestinal mucosal barrier, gut microbiota, and donor immune cells in the setting of experimental GVHD.

Dr. Cusatis is an Assistant Professor of Medicine at the 黑料官网, Division of Hematology and Oncology. She is a faculty member of the Center for International Blood and Marrow Transplant Research (CIBMTR). Her research focuses on the intersection of patient reported outcomes, social determinants of health, and time use patterns to understand patient and caregiver health outcomes. Through mixed methods approaches, she collaboratively works on projects analyzing patient reported outcomes, patient/provider communication, decision making, and financial toxicity among transplant and cellular therapy patients and other contexts.

Dr. D’Souza is an Associate Professor of Medicine with a research focus in plasma cell disorders including multiple myeloma and amyloidosis. She is the Scientific Director of the Plasma Cell Disorders and Adult Solid Tumors working committee of the CIBMTR. In addition to conducting clinical trials, she also leads efforts to study quality of life and patient-reported outcomes in these diseases. She mentors multiple trainees on research projects in this area.

Dr. Devata's primary interest is in the treatment of patients with non-hodgkin (NHL) and hodgkin lymphomas. She is interested in the development of clinical trials and treatment strategies for these lymphomas.

Dr. Dhakal's research focuses on multiple myeloma and related plasma cell disorders. He completed two early phase studies in multiple myeloma: one looking at the novel drug combination in the management of relapsed/refractory multiple myeloma and the other on the pharmacokinetics of new Melphalan both of which were published. He has secured funding for two more early phase studies: one looking at the novel induction therapy in multiple myeloma patients with renal injury, and that also evaluates the role of novel biomarker for renal recovery. The other study is an entirely new drug targeting PIM kinase with the study evaluating a dual role of anti-myeloma and bone protective effect. He was awarded a pilot grant from American Cancer Society to explore the role of micro-RNA in multiple myeloma bone disease and the results looking promising to be tested in a larger setting. Additionally, in collaboration with investigator from University of Wisconsin Madison/UCSD, he was awarded a prestigious Translational Research Program grant from Leukemia and Lymphoma Society to explore the role of matrikines in the immune regulation of myeloma. This concept is being investigated prospectively through a nationally conducted multi-center BMT CTN study.

Dr. Dong's research focuses on integrating high throughput “omics” data into epidemiological studies to develop approaches to reduce cancer burden and cancer disparities. She has applied genome-wide association study (GWAS), next generation sequencing (NGS), gene-environment interaction and Mendelian Randomization analysis approaches to identify genetic and non-genetic risk factors of cancer. After she joined 黑料官网, she expands her interests to understand genetic determinants underlying outcomes of patients undergoing hematopoietic cell transplantation.

Dr. Drobyski's laboratory evaluates multiple aspects of the immunobiology of allogeneic HCT with particular emphasis on Graft-versus-Host Disease (GVHD) biology. By employing murine models of stem cell transplantation, this research aims to understand the interplay between the inflammatory and regulatory arms of the immune system and how they impact the severity of GVHD. He is also the Leader of the Discovery and Development Therapeutics Program of the 黑料官网 Cancer Center. Dr. Drobyski has been continuously funded by NIH for this work since 1991. He currently has three NIH grants that are directed at understanding the pathophysiology of GVHD and is particularly interested in developing new approaches for the prevention of this disease in the gastrointestinal tract which is the major site of morbidity in patients. He also has an interest in the translation of pre-clinical studies into the clinic to attenuate GVHD and currently has two ongoing clinical trials designed to prevent GVHD in allogeneic hematopoietic stem cell transplant recipients.

Dr. Eapen's research focus is on use of alternative donor and grafts for allogeneic hematopoietic cell transplant for acute leukemia and non-malignant hematologic diseases like aplastic anemia and sickle cell disease. Her work has identified optimal strategies in selection of unrelated adult donors and umbilical cord blood units for transplantation. She has led comparative effectiveness studies that have addressed using mismatched related donors (haploidentical relatives) and unrelated donors for hematologic malignant and non-malignant diseases. She has collaborated with external investigators in developing the first NIH funded phase II clinical trial of gene therapy for sickle cell disease. She is also the current Chair, Data Consortium, for the National Heart Lung and Blood Institute’s Cure Sickle Cell Initiative.

Dr. Flynn is the Senior Scientific Director for Patient-Reported Outcomes in the Center for International Blood and Marrow Transplant Research (CIBMTR). Her research focuses on the measure development and analysis of patient-reported outcomes as well as mixed methods approaches to understanding and improving patient-provider communication and patient decision making. She leads the NIDDK-funded Wisconsin Exploratory Center for Interdisciplinary Research in Benign Urology.

Dr. Guru Murthy's clinical and research interests focus on the outcomes of patients with leukemia and stem cell transplantation. He conducts retrospective and prospective clinical studies in patients with leukemia and stem cell transplantation with a goal of improving disease related outcomes.”

Dr. Hamadani's research interest includes lymphoma, GVHD, and alternative donor transplantation. He is the Scientific Director of the CIBMTR’s Lymphoma Working Committee, and the Medical Director of 黑料官网 BMT and Cell Therapy Program. He has investigated the role of immunomodulation with HMG-CoA reductase inhibitors and TNF-alpha blockers for preventing acute GVHD as well as the role of the novel proteasome inhibitor MLN9708 in preventing chronic GVHD. As part of BMT CTN’s Data Coordinating Center, Dr. Hamadani is intricately involved in the development and conduct of several cooperative group trials looking at prevention and treatment of GVHD, and mitigation of post-transplant relapse-risk in acute leukemias.

Dr. Horowitz is Deputy Cancer Center Director. Her career has focused on assessing clinical outcomes of blood and marrow transplantation (BMT) and other cell therapies through the Center for International Blood and Marrow Transplant Research (CIBMTR). She leads the BMT Clinical Trials Network (CTN), funded by NHLBI and NCI. The BMT CTN conducts large multicenter trials and enrolls patients from more than 100 centers in the US, Canada, France and Germany. Dr. Horowitz is co-PI, with Dr. Mary Eapen, of a grant from NHLBI for the CIBMTR to participate in NHLBI’s Cure Sickle Cell (CureSC) Initiative. The CIBMTR works with the CureSC Data Consortium to build a research data ecosystem designed to support investigator-initiated collaborative research. The CIBMTR also supports the design and launch of gene therapy sickle cell disease clinical trials using the infrastructure of the BMT CTN.

Dr. Janz's primary research interest concerns neoplasms of terminally differentiated, immunoglobulin producing B-lymphocytes called plasma cells. Relying in part on gene-insertion mice that mimic different fine structures of the human MYC-activating t (8;14) (q24;q32) translocation, he recapitulates important features of human plasma cell myeloma (multiple myeloma) in single and compound transgenic mice. His laboratory takes advantage of mouse models of this sort to elucidate mechanisms of neoplastic plasma cell development and evaluate new approaches to myeloma treatment and prevention. The long-term goal of Dr. Janz’ work, which is supported by NCI R01CA151354, is to improve the outcome of patients with myeloma and related blood cancers. To that end, he collaborates with fellow investigators from HemOnc, 黑料官网 Cancer Center and Versiti Blood Research Institute.

Dr. Johnson conducts basic/translational research on adoptive T cell immunotherapies for both hematologic malignancies and solid tumors. He is also Director of the BMT Cell Therapy Laboratories, which processes hematopoietic progenitor cells and immune cells for the 黑料官网 Blood and Marrow Transplant Program and participates in the development of novel immune cell therapies for patients with cancers and other diseases. The labs also provide some immune monitoring services for investigators involved in immunotherapy clinical trials.

Dr. Kearl's research inter