Dwinell Laboratory

Location
Microbiology & Immunology
TBRC C3860

General Interests
Cancer Progression and the Tumor Immune Microenvironment

Research Areas

My research has been investigating the cellular, biochemical, molecular and pathophysiologic mechanisms controlling cellular movement in inflammation and cancer. The movement of cells within and between tissues is a fundamental property of biology. Cell movement / migration, may have beneficial effects, for example in wound healing or leukocyte trafficking, or deleterious effects, such as in the invasion and metastasis of tumor cells. My laboratory uses a spectrum of cellular, molecular, metabolomic and biochemical techniques, in combination with an array of cell culture and preclinical transgenic mouse models, to dissect the details of how cells move and the functional consequences of that movement. As chemokines are the archetype immune molecules directing cell movement, the investigative focus of my research program is to resolve the mechanisms of chemokine signaling in order to improve human health through the design of new chemokine-targeted or immune targeted therapies to disrupt or promote cellular movement in inflammation and cancer.

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Research Support

Research in the Dwinell laboratory is supported through grants from the National Institutes of Health, long standing support from the Bobby Nick Voss Charitable Foundation, the 黑料官网 Cancer Center and philanthropic donations.

Current Members

Kathleen Boyle, PhD

Adjunct Assistant Professor

kboyle@mcw.edu

Donovan Drouillard

G4 Student

ddrouillard@mcw.edu

Donna McAllister

Lab Supervisor, Dwinell Lab

dmcallis@mcw.edu

Maria Poimenidou

Graduate Student

mpoimenidou@mcw.edu

Elisabeth Solis

Graduate Student

esolis@mcw.edu

(Drouillard D, Poimenidou M, Davies M, McAllister D, Clarke WR, Hwang ST, Peterson FC, Volkman BF, Dwinell MB.) Cell Biol Toxicol. 2025 Dec 19;42(1):14 PMID: 41419693 PMCID: PMC12799736 SCOPUS ID: 2-s2.0-105027326723 12/20/2025
(Mao C, Poimenidou M, McAllister D, Dwinell MB, Craig BT.) Immunohorizons. 2025 Nov 09;9(11) PMID: 41208108 PMCID: PMC12597879 SCOPUS ID: 2-s2.0-105021199974 11/10/2025
(Drouillard D, Halyko M, Cinquegrani E, Poimenidou M, Emosivbe M, McAllister D, Peterson FC, Marchese A, Dwinell MB.) Sci Rep. 2025 Jul 22;15(1):26625 PMID: 40696056 PMCID: PMC12284246 SCOPUS ID: 2-s2.0-105011283426 07/23/2025
(Shah NN, Colina AS, Johnson BD, Szabo A, Furqan F, Kearl T, Schneider D, Vargas-Cortes M, Schmeling JL, Dwinell MB, Palen K, Longo W, Hematti P, Zamora AE, Hari P, Bucklan D, Cunningham A, Hamadani M, Fenske TS.) J Clin Oncol. 2025 Jul 10;43(20):2285-2295 PMID: 40163793 SCOPUS ID: 2-s2.0-105010720202 03/31/2025
(Espinosa OV, Awan M, Memon AA, Frei A, Foeckler J, Kuehn R, Bruening J, Massey B, Wong S, Shukla M, Kasprzak J, Joshi A, Dwinell MB, Himburg HA, Zenga J.) Head Neck. 2025 May;47(5):1379-1391 PMID: 39722591 PMCID: PMC12040585 SCOPUS ID: 2-s2.0-85212965471 12/26/2024
(Roy I, Binder-Markey B, Willbanks A, Sychowski D, Phipps T, Barber A, McAllister D, D'Andrea D, Franz CK, Pichika R, Dwinell MB, Lieber RL.) J Appl Physiol (1985). 2024 Sep 01;137(3):705-717 PMID: 39052773 PMCID: PMC11424168 SCOPUS ID: 2-s2.0-85204163300 07/26/2024
(Roy I, Binder-Markey B, Sychowski D, Willbanks A, Phipps T, McAllister D, Bhakta A, Marquez E, D'Andrea D, Franz C, Pichika R, Dwinell MB, Jayabalan P, Lieber RL.) bioRxiv. 2023 Nov 15 PMID: 38014165 PMCID: PMC10680669 11/28/2023
(Keyes RF, McAllister D, Dwinell MB, Smith BC.) STAR Protoc. 2023 Sep 15;4(3):102437 PMID: 37552599 PMCID: PMC10424135 SCOPUS ID: 2-s2.0-85175638505 08/08/2023
(Mohan M, Janz S, Brazauskas R, Dwinell MB, Teng BQ, Yun G, Dong J, Pasquini MC, Giralt S, Landau H, Stadtmauer E, Krishnan A, D'Souza A.) Bone Marrow Transplant. 2023 Aug;58(8):953-955 PMID: 37149674 PMCID: PMC10555486 SCOPUS ID: 2-s2.0-85158126520 05/07/2023
(Zhou AL, Jensen DR, Peterson FC, Thomas MA, Schlimgen RR, Dwinell MB, Smith BC, Volkman BF.) SLAS Discov. 2023 Jun;28(4):163-169 PMID: 36841432 PMCID: PMC10339762 SCOPUS ID: 2-s2.0-85149845436 02/26/2023
(Wu X, Clarke WR, Koplinski CA, Peterson FC, Dwinell MB, Wei G, Chao E, Huynh M, Yamada D, Volkman BF, Hwang ST.) J Immunol Methods. 2023 Apr;515:113453 PMID: 36863695 PMCID: PMC10715733 SCOPUS ID: 2-s2.0-85150034077 03/03/2023
(Elmansi AM, Eisa NH, Periyasamy-Thandavan S, Kondrikova G, Kondrikov D, Calkins MM, Aguilar-Pérez A, Chen J, Johnson M, Shi XM, Reitman C, McGee-Lawrence ME, Crawford KS, Dwinell MB, Volkman BF, Blumer JB, Luttrell LM, McCorvy JD, Hill WD.) ACS Pharmacol Transl Sci. 2023 Jan 13;6(1):22-39 PMID: 36659961 PMCID: PMC9844133 01/21/2023
(Vonderhaar EP, Dwinell MB, Craig BT.) Front Immunol. 2023;14:1202169 PMID: 37426669 PMCID: PMC10325564 SCOPUS ID: 2-s2.0-85164152167 07/10/2023
(Elmansi AM, Eisa NH, Periyasamy-Thandavan S, Kondrikova G, Kondrikov D, Calkins MM, Aguilar-Pérez A, Chen J, Johnson M, Shi XM, Reitman C, McGee-Lawrence ME, Crawford KS, Dwinell MB, Volkman BF, Blumer JB, Luttrell LM, McCorvy JD, Hill WD.) ACS Pharmacology and Translational Science. 13 January 2023;6(1):22-39 SCOPUS ID: 2-s2.0-85143982229 01/13/2023

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Media

View images and video from the 黑料官网 Dwinell Lab.

Flashback

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2017

Wearing purple for World Pancreatic Cancer Day

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2013

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2010

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Lab Alumni

Hong Guan, MS

Doctoral Candidate, Department of Chemistry and Biochemistry, University of South Carolina

Ishan Roy, MD, PhD

Clinical Instructor & Chief Resident Physician; Department of Physical Medicine & Rehabilitation, Northwestern University/Shirley Ryan Ability Lab

Natasha Moussouras, PhD

Research Fellow, Department of Microbiology & Immunology, 黑料官网

Emily Vonderhaar, PhD

Clinical Research Training Fellow, Department of Microbiology & Immunology, 黑料官网

Jonathan D. Van Wickle

Resident, Radiation Oncology, University of Iowa

Eric A. Luedke, MD

General Surgery, Sharp Memorial Hospital, Stanford Health Care-Stanford Hospital, San Diego, CA.

Yana Thaker, MD

General Internal Medicine, Gastroenterology, University of Washington, Seattle, WA

Joanne P Boisvert (Hayes), MD

Family Medicine Practice, Madras, OR

Egal I. Gorse, MD

2018- Fellowship Hematology and Medical Oncology, Emory University School of Medicine 2020 Recipient Nell W. and William Simpson Elkin Fellowship

Kimberle A Agle. PhD

Scientist-II, Immucor, Inc, Waukesha, WI

Amanda N. Cooper, MD

Private Practice, Dermatology, Germantown, WI

Luke J. Drury, PhD

Human Molecular Geneticist, Prevention Genetics, Marshfield Clinic, Marshfield, WI

Sheena L. Faherty

Science Writer, National Human Genome Research Institute (NHGRI), National Institutes of Health (NIH), Bethesda, MD

Soonyean Hwang, PhD

Postdoctoral Fellow, Dana-Farber Cancer Institute, Harvard Cancer Center, Mentor: Martin E. Hemler, PhD

Priscilla A. Johanesen, PhD

Associate Professor (Tenured), Deputy Head of Department (Education), Department of Microbiology, Monash University, Melbourne, AUSTRALIA

Jennifer M. Boardman (Smith), PhD

Assistant Dean for Academic Affairs for the School of Graduate Studies, Associate Professor, Microbiology and Immunology, Department of Basic Sciences, Geisinger

Rebecca A. Vongsa, PhD

Scientist-III, Kimberly-Clark Corp., Skin Health and Infection Control Health Care Division, Appleton, WI

Michael K. Wendt, PhD

Associate Professor, Purdue University, Lafayette, IN

Noah P. Zimmerman, PhD

Research Manager, Arm and Hammer, Waukesha, WI

Mahmoud Abu Eid, PhD
Consultant, McKinsey & Company

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