黑料官网

Purpose
A systematic approach to the evaluation and management of concussion and evidence-based recommendations for early activity could improve the quality of life for many children. This randomized clinical trial of active rehabilitation and quality improvement initiative will inform and improve the care of pediatric concussion in the emergency department.

Funding
Centers for Disease Control, U01

Study Lead
Danny Thomas, MD, MPH

Purpose
To assess the impact of violence on youth outcomes utilizing fMRI and machine learning we will enroll youth victims of violence and follow their outcomes longitudinally. Analysis will focus on protective and negative associations on mental health outcomes including PTSD, Anxiety, and Depression.

Funding
NIH Mental Health

Study Lead
Michael Levas, MD, MS

Purpose
Initiative in the CW emergency department designed to screen and address food insecurity in families. The initiative includes incorporating food insecurity questions into the emergency department workflow, providing families with community resources, and connecting families in need of additional assistance with the Family Resource Center.

Funding
Children’s Wisconsin

Study Lead
Michael Levas, MD, MS

Purpose
The primary objective of the current study is an evaluation of the safety and efficacy of Azithromycin (AZ) for the treatment of wheezing and lower respiratory illness in children ages 2-5.

Funding
NIH Heart Lung and Blood Institute

Study Lead

Purpose
The purpose of this multi-center study is to identify a set of rules that can be used to exclude a diagnosis of pulmonary embolism in children. The study prospectively examines the sensitivity and specificity of the PERC-Peds criteria as well as the diagnostic accuracy of d-dimer.

Funding
NIH Heart Lung and Blood Institute

Study Lead
Megan Schultz, MD, MA

Purpose
Multi-center prospective observational study of children who have sustained blunt trauma and may be at risk of cervical spine injury (CSI). The investigators aim to develop and test a pediatric cervical spine injury risk assessment tool that can be used by EMS and ED providers to determine which children warrant spinal precautions and cervical spine imaging after blunt trauma.

Funding
NIH Child Health and Human Development

Study Lead
Lorin Browne, DO

Purpose
This is a prospective observational cohort study to develop an imaging decision rule for pediatric patients who present to the ED with headache.

Funding
NIH Neurological Disorders and Stroke

Study Lead
Danny Thomas, MD, MPH

Purpose
The purpose of this grant is to fund the infrastructure that allows CW/MCW participate in the HOMERUN node of the Pediatric Emergency Care Applied Research Network.

Funding
HHS Health Resources and Services Administration

Study Lead
Danny Thomas, MD, MPH

Purpose
A prospective multi-center, longitudinal comparative effectiveness study that capitalizes on the known variability in pain treatment to determine the most effective analgesic regimen for children with fracture pain. The long-term goal is to improve the treatment of injured children. The overall goal of the study is to evaluate and provide evidence for both ED and post-ED pain treatment for children with fracture-related pain.

Funding
NIH Child Health and Human Development, R01

Study Lead
Amy Drendel, DO, MS

Novel Diagnostics for Children with Lyme Disease

Purpose
To optimize the timely diagnosis of Lyme disease in order to target appropriate therapies to those with confirmed disease.

Study Lead
Michael Levas, MD, MS

Purpose
The scope of work will be to develop and validate an evidence-based tool for identification of children at low-risk for cervical spine injury following blunt trauma.

Funding
HHS Health Resources and Services Administration

Study Lead
Lorin Browne, DO

Purpose
For children ages 8-17 years old with long-bone fractures who are discharged home from the ED, we will compare the short-term pain outcomes reported by children using text messages to pain outcomes reported by their parents to comprehensively describe the outpatient pain experience, an area that is currently lacking.

Funding
Children’s Research Institute

Study Lead
Keli Coleman, MD

Purpose
This is a randomized clinical trial aimed to determine the clinical effectiveness of balanced crystalloids vs normal saline in children resuscitated for septic shock as a part of usual clinical practice.

Funding
NIH Child Health and Human Development

Study Lead
Shannon Baumer-Mouradian, MD

Purpose
The study is a phase 3 randomized, placebo-controlled trial of IV arginine vs. placebo in patients with sickle cell disease age 3-21 years who present for acute management of vaso-oclusive pain episodes requiring parenteral opioids. Children’s Wisconsin is 1 of 10 clinical sites in the US that will participate in this study, endorsed by the Pediatric Emergency Care Applied Research Network (PECARN).

Funding
NIH Heart Lung and Blood Institute

Study Lead
David Brousseau, MD, MS

Purpose
This study, which seeks to compare a targeted screening strategy (screening only those disclosing high risk sexual behavior) to a universally-offered screening strategy (offered to all, regardless of risk) by integrating patient-reported data into the electronic health record for the provision of clinical decision support through a multicenter comparative effectiveness pragmatic trial, will develop the evidence base for creating cost-effective and sustainable STI screening programs that can be successfully implemented in to the clinical workflow of the ED.

Funding
Children’s Research Institute-Children’s National Health System-DC

Study Lead
Michelle Pickett, MD, MS

Purpose
This is a prospective study that will utilize parent interviews and focus groups to evaluate the impact of racial and ethnic backgrounds on parental vaccine hesitancy for administration of pediatric influenza and SARS-CoV-2 vaccines. The study will seek to identify culturally sensitive interventions that will facilitate these pediatric vaccinations.

Funding
Children’s Research Institute

Study Lead
Shannon Baumer-Mouradian, MD

Purpose
The objective of the study is to decrease pediatric suicide throughout the CW health system by utilizing prevention strategies and improvement in mental health outpatient resource utilization.

Funding
Children鈥檚 Research Institute

Study Lead
Michelle Pickett, MD, MS

Pediatric Procedural Sedation and the Relationship with Post-Discharge Negative Behavioral Changes in the Emergency Department

Purpose
Determine if a pre-sedation virtual reality intervention will decrease pre-sedation anxiety levels and post-sedation negative behavioral changes in children undergoing procedural sedation with IV ketamine in the ED following discharge home.

Study Lead
Keli Coleman, MD

Clean catch urine samples may replace first void urine samples for diagnosing chlamydia and gonorrhea in adolescent females

Purpose
Compare the sensitivity of clean catch samples to first catch urine, an acceptable diagnostic method, and vaginal swabs, the current optimal standard, in adolescent females at risk for chlamydia and gonorrhea.

Study Lead
Michelle Pickett, MD, MS

Established Status Epilepticus Treatment Trial

Purpose
To determine the most effective and/or the least effective treatment of benzodiazepine-refractory SE among children 2 years or older and to determine the relative safety profile of the treatment.

Study Lead
Danny Thomas, MD, MPH

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Morrison, A. K., Nimmer, M., & Ferguson, C. C. (2021). Leveraging the Electronic Medical Record to Increase Distribution of Low Literacy Asthma Education in the Emergency Department. Academic Pediatrics, 21(5), 868–876.

Pickett, M. L., Krentz, C., Nimmer, M., Servi, A., Schmitz, A., & Drendel, A. L. (2021). Implementation of a tablet-based suicide screening tool in an emergency department. The American Journal of Emergency Medicine, 42, 256–257.

Pickett, M. L., Visotcky, A., Brazauskas, R., Ledeboer, N. A., & Drendel, A. L. (2021). Can a Clean Catch Urine Sample Be Used to Diagnose Chlamydia and Gonorrhea in Adolescent Females? Journal of Adolescent Health, S1054139X21001075.

Zembles, T., Zhan, Y., Chiu, A., Brousseau, D. C., & Vyles, D. (2021). Cephalosporin allergy symptoms in children presenting to a pediatric emergency department. Annals of Allergy, Asthma & Immunology, S108112062100329X.

Singh A, Dasgupta M, Simpson PM, Brousseau DC, Panepinto JA. Can PROMIS domains of pain and physical functioning detect changes in health over time for children with sickle cell disease? Pediatric Blood & Cancer. 2020;67(5). doi:

Schonfeld DJ, Melzer-Lange M, Hashikawa AN, Gorski PA, Council on children and disasters, council on injury, violence, and poison prevention, council on school health. Participation of Children and Adolescents in Live Crisis Drills and Exercises. Pediatrics. 2020;146(3):e2020015503. doi:

Pickett ML, Krentz C, Nimmer M, Servi A, Schmitz A, Drendel AL. Implementation of a tablet-based suicide screening tool in an emergency department. The American Journal of Emergency Medicine. Published online June 2020. doi:

Pickett ML, Lee J, Brousseau DC, Satterwhite C, Ramaswamy M. Correlates of sexually transmitted infection testing following women’s release from jail: Correlates of STI testing following incarceration. Women & Health. 2020;60(10):1109-1117. doi:

Nigrovic LE, Lewander DP, Balamuth F, Neville DN, Levas MN, Bennett JE, Garro A for Pedi Lyme Net. The Lyme Disease Polymerase Chain Reaction Test Has Low Sensitivity. Vector-Borne and Zoonotic Diseases. 2020;20(4):310-313. doi:

Nigrovic LE, Bennett JE, Balamuth F, Levas MN, Neville D, Lyons TW, Branda JA, Maulden AB, Lewander D, Garro A for Pedi Lyme Net. Diagnostic Performance of C6 Enzyme Immunoassay for Lyme Arthritis. Pediatrics. 2020;145(1):e20190593. doi:

Nguyen P, Ferguson CC. Perspective Differences Between Attending Physician and Medical Student. Zink BJ, ed. Academic Emergency Medicine. Published online May 31, 2020. doi:

Nelson A, Singh, Dasgupta M, Simpson PM, Chiu A, Brousseau DC, Panepinto JA. Assessment of pediatric asthma exacerbation with the use of new PROMIS measures. Journal of Asthma. Published online July 9, 2020:1-9. doi:

Muslu CS, Kopetsky M, Nimmer M, Visotcky A, Fraser R, Brousseau DC. The association between timely opioid administration and hospitalization in children with sickle cell disease presenting to the emergency department in acute pain. Pediatric Blood & Cancer. 2020;67(9). doi:

Lerner EB, Badawy M, Cushman JT, Drendel AL, Fumo N, Jones CMC, Shah M, Gourlay DM. Does Mechanism of Injury Predict Trauma Center Need for Children? Prehospital Emergency Care. Published online March 24, 2020:1-8. doi:

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Fowler M, Ali S, Gouin S, Drendel AL, Poonai N, Yaskina M, Sivakumar M, Jun E, Dong K. Knowledge, attitudes and practices of Canadian pediatric emergency physicians regarding short-term opioid use: a descriptive, cross-sectional survey. CMAJ Open. 2020;8(1):E148-E155. doi:

Dribin TE, Sampson HA, Camargo CA, Brousseau DC, Spergel JM, Neuman MI, Shaker M, Campbell RL, Michelson KA, Rudders SA, Assa’ad AH, Risma KA, Castells M, Schneider LC, Wang J, Lee J, Mistry RD, Vyles D, Vaughn LM, Schumacher DJ, Witry JK, Viswanathan S, Page EM, Schnadower D. Persistent, refractory, and biphasic anaphylaxis: A multidisciplinary Delphi study. Journal of Allergy and Clinical Immunology. Published online August 2020. doi:

Drendel AL, Brousseau DC, Casper TC, Bajaj L, Alessandrini EA, Grundmeier RW, Chamberlain JM, Goyal MK, Olsen CS, Alpern ER. Opioid Prescription Patterns at Emergency Department Discharge for Children with Fractures. Pain Medicine. 2020;21(9):1947-1954. doi:

Brousseau DC, Muslu CS, Visotcky A, Fraser R, Kavanagh PL, Chelius TH, Schuh AM. Teaching Versus Nonteaching Hospitals: Where Children With Sickle Cell Disease Receive Their Emergency Department Care. Journal of Pediatric Hematology/Oncology. 2020;42(6):412-413. doi:

Baumer-Mouradian SH, Kleinschmidt A, Servi A, Jaworski B, Lazarevic K, Kopetsky M, Nimmer M, Hanson T, Gray MP, Drendel AL. Vaccinating in the Emergency Department, a Novel Approach to Improve Influenza Vaccination Rates via a Quality Improvement Initiative. Pediatric Quality & Safety. 2020;5(4):e322. doi:

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Pickett ML, Hoehn EF, Visotcky AM, Norman B, Drendel AL. Adolescents’ Awareness of and Attitudes Toward Expedited Partner Therapy Provided in the Emergency Department. Sexually Transmitted Diseases. 2020;47(11):754-759. doi:

Morrison AK, Nimmer M, Ferguson CC. Leveraging the Electronic Medical Record to Increase Distribution of Low Literacy Asthma Education in the Emergency Department. Academic Pediatrics. Published online November 2020. doi:

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Howe JL, Reed JL, Adams KT, et al. Workflow Analysis Driven Recommendations for Integration of Electronically-Enhanced Sexually Transmitted Infection Screening Tools in Pediatric Emergency Departments. Journal of Medical Systems. 2020;44(12). doi:

Hodapp JW, Ali S, Drendel AL. Bringing It All Together: A Review of the Challenges in Measuring Children’s Satisfaction as a Key Component of Acute Pain Management. Children. 2020;7(11):243. doi:

Hatkevich C, Grupp-Phelan J, Brent D, et al. Understanding adolescent responses to differently worded suicide attempt questions: Results from a large U.S. pediatric sample. Psychological Medicine. Published online December 2, 2020:1-29. doi:

Browne L, Ahmad F, Schwartz H, et al. Prehospital Factors Associated with Cervical Spine Injury in Pediatric Blunt Trauma Patients. Academic Emergency Medicine. Published online November 20, 2020. doi:

Howe JL, Reed JL, Adams KT, et al. Workflow Analysis Driven Recommendations for Integration of Electronically-Enhanced Sexually Transmitted Infection Screening Tools in Pediatric Emergency Departments. Journal of Medical Systems. 2020;44(12). doi:

Hodapp JW, Ali S, Drendel AL. Bringing It All Together: A Review of the Challenges in Measuring Children’s Satisfaction as a Key Component of Acute Pain Management. Children. 2020;7(11):243. doi:

Hatkevich C, Grupp-Phelan J, Brent D, et al. Understanding adolescent responses to differently worded suicide attempt questions: Results from a large U.S. pediatric sample. Psychological Medicine. Published online December 2, 2020:1-29. doi:

Browne L, Ahmad F, Schwartz H, et al. Prehospital Factors Associated with Cervical Spine Injury in Pediatric Blunt Trauma Patients. Academic Emergency Medicine. Published online November 20, 2020. doi:

Addesso LC, Nimmer M, Visotcky A, Fraser R, Brousseau DC. Impact of Medical Scribes on Provider Efficiency in the Pediatric Emergency Department. Academic Emergency Medicine. 2019;26(2):174-182.

Drendel AL, Gray MP, Lerner EB. A Systematic Review of Hospital Trauma Team Activation Criteria for Children. Pediatric Emergency Care. 2019;35(1):8-15.

Fischer KR, Bakes KM, Corbin TJ, Fein JA, Harris EJ, James TL, Melzer-Lange MD. Trauma-Informed Care for Violently Injured Patients in the Emergency Department. Annals of Emergency Medicine. 2019;73(2):193-202.

Garro A, Bennett J, Balamuth F, Levas MN, Neville D, Branda JC, Maulden AB, Lantos PM, Nigrovic LE. Positive Two-tiered Lyme Disease Serology is Uncommon in Asymptomatic Children Living in Endemic Areas of the US. The Pediatric Infectious Disease Journal. 2019;38(5):e105-e107.

Kuppermann N, Dayan PS, Levine DA, Vitale M, Tzimenatos L, Tunik MG, Saunders M, Ruddy RM, Roosevelt G, Rogers AJ, Powell EC, Nigrovic LE, Muenzer J, Linakis JG, Grisanti K, Jaffe DM, Joyle JD Jr, Greenberg R, Gattu R, Cruz AT, Crain EF, Cohen DM, Brayer A, Borgialli D, Bonsu B, Browne L, Blumberg S, Bennett JE, Atabaki SM, Anders J, Alpern ER, Miller B, Casper TC, Dean JM, Ramilo O, Mahajan P, Febrile Infant Working Group of the Pediatric Emergency Care Applied Research Network (PECARN). A Clinical Prediction Rule to Identify Febrile Infants 60 Days and Younger at Low Risk for Serious Bacterial Infections. JAMA Pediatrics. 2019 (In press).

Lepley BE, Brousseau DC, May MF, Morrison AK. Randomized Controlled Trial of Acute Illness Educational Intervention in the Pediatric Emergency Department: Written Versus Application-Based Education. Pediatric Emergency Care. 2019 (In press).

Maulden AB, Garro AC, Balamuth F, Levas MN, Bennett JE, Neville DN, Branda JA, Nigrovic LE, for Pedi Lyme Net. Two-Tier Lyme Disease Serology Test Results Can Vary According to the Specific First-Tier Test Used. Journal of the Pediatric Infectious Diseases Society. 2019 (In press).